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To find the best evidence you need to:
PICOT is one framework for building a clinical question.
The following resources will step you through the process of creating an answerable question:
Formulate a clinical question
Self-directed online tutorial (from the University of Western Australia, Faculty of health and medical sciences)
PICOT part 1 / PICOT part 2
Two videos produced by Wolters Kluwer - providers of Ovid databases
You can also consider alternatives to PICO. This academic paper outlines some alternatives including COPES, ECLIPSE, PIPOH, PECODR etc) based on field of study (eg: medicine, OT, social work, speech pathology, oncology etc).
Introduction to Evidence-Based Practice from Duke University Medical Center Library and the Health Sciences Library at University of North Carolina