Research

Clinical trials

Researchers at Austin LifeSciences often run clinical trials that need participants from the local community.

All clinical trials conducted at Austin Health are done so under Australian and International guidelines for medical research under the approval of Austin Health Human Research Ethics Committee (HREC).

If you are an Austin LifeSciences researcher and would like to list a trial here, please email a request with a copy of your HREC-approved advertisement to geraldine.richards@austin.org.au

Alzheimer's Disease (several studies)

The Medical and Cognitive Research Unit is currently recruiting for clinical studies of the effectiveness and safety of a number of investigational products that may help slow the progression of mild to moderate Alzheimer's disease.

To be considered for study participation you must be

  • Under 90 years old
  • Have an Alzheimer's disease diagnosis
  • Have symptoms of mental or functional decline dating back at least 1 year
  • Have a partner or caregiver who is willing to bring you to study visits and help you follow the study requirements

Other eligibility requirements apply.

Study-related medication and care will be provided at no cost.

For more information about the potential benefits and risks of the study, please contact the research team on 9496 2823 or via email

 

Seeking healthy seniors for clinical research study on cognitive health

The TOMMORROW study seeks to learn more about the genetic risk for developing mild cognitive impairment due to Alzheimer's disease and whether an investigational medication might prove effective in delaying the first symptoms of this condition.

You may be eligible to participate in this important study if you are:

  • 65 to 83 years of age
  • in good physical and mental health

To learn more:
(03) 9496-2421 or email  Lauren.Grimwood@austin.org.au

 

Breathing and Sleep (two studies)

Participants needed: Healthy 22 - 45 year old patients with untreated Obstructive Sleep Apnoea

The Sleep Research Laboratory at University of Melbourne and the Institute for Breathing and Sleep at Austin Health are recruiting obstructive sleep apnoea patients, 30-45 years old, for a study on memory and mood. Participation involves a 1.5 hour session at the Sleep Laboratory, where you will be asked to complete some questionnaires and memory tasks. Participants will be reimbursed for their time. University of Melbourne HREC#1239101. Enquiries: Melinda Jackson 90356129

Diabetes (five studies/trials)

Do you have type 2 diabetes? Do you have problems with your kidneys?

If the answer to both questions is Yes, you may be able to take part in a clinical research study.
The CREDENCETM Study is looking at an investigational (study) medication (taken as a daily capsule) that may help protect the kidneys in people with type 2 diabetes.
We are looking for people who:

• Are 30 years of age or older
• Have a diagnosis of type 2 diabetes
• Have kidney problems related to their diabetes
• Are currently taking medicines to control their kidney problems

If you choose to take part in the CREDENCETM Study, you will be looked after by an experienced study team who will carefully monitor your health and support your diabetes management. You will continue to take your current diabetes medications.

For more information please contact: Nicky Robinson on 9496 2645 or ClinicalTrials-UoMRepat@unimelb.edu.au

This study has been approved by the Austin Health Human Research Ethics Committee. HREC: 28431754DNE3001

Heart Attack...Stroke.... Are you at risk?

Heart attacks can happen at any time to anyone. It is important to know if you are at risk. There are many factors that increase your chances of having a heart attack including:
• Previous Heart Attack
• Heart Related Disease
• High Cholesterol
• High Blood Pressure
• Diabetes
Local physicians are conducting a research study of an investigational medication and its ability to reduce your risk of having a heart attack and other cardiovascular events such as a stroke. If you are currently taking a medication to lower your cholesterol and have one or more of the conditions listed above, you may qualify for participation in this study. All testing, treatment and parking will be provided free of charge. This project has been approved by the Austin Health and St Vincent's Hospital (Melbourne) Human Research Ethics Committee: HREC 12/SVHM/1.
If interested, please contact Nicky Robinson from the Metabolic Disorders Centre, Heidelberg Repatriation Hospital on 03 9496 2645 or nbric@unimelb.edu.au

Do you have Type 2 Diabetes?

We are testing the effect of an investigational drug on cardiovascular events (heart attack and stroke) in patients with Type 2 Diabetes who may be at risk of these events. If you are male or female aged 50 years or older have Type 2 Diabetes and have never had a heart attack or stroke, you may qualify for a clinical trial. You will be medically supervised. There will be no costs involved. Visits are at the Metabolic Disorders Centre, Austin Health, Heidelberg Repatriation Hospital. This project has been approved by the Austin Health and St Vincent’s Hospital (Melbourne) Human Research Ethics Committee D: HREC D513BC00001.
If interested, please contact Nicky Robinson from the Metabolic Disorders Centre, Heidelberg Repatriation Hospital on 03 9496 2645 or nbric@unimelb.edu.au

Obesity Study - We are seeking volunteers

We are currently studying the effects of a clinical trial medication in overweight patients with a history of Heart Disease, Type 2 Diabetes and Multiple Cardiac Risk Factors. We are currently looking for volunteers with one or more of the conditions listed below:
• Previous Heart Attack
• Angioplasty or Heart Bypass Surgery
• Previous Stroke or Carotid Surgery
• A blocked artery in the leg which causes symptoms (pain, reduced walking)
• Previous vascular surgery or amputation of lower limbs
• Diabetes with high Cholesterol and /or high Blood and/or reduced kidney function
This is a large investigational study involving approximately 12,000 patients worldwide. Trial visits are held at the Metabolic Disorders Centre, Austin Health, Heidelberg Repatriation Hospital. All testing, treatment and parking will be provided free of charge. This project has been approved by the Austin Health and St Vincent's Hospital (Melbourne) Human Research Ethics Committee D: HREC APD356-G000401.
If interested, please contact Nicky Robinson from the Metabolic Disorders Centre, Heidelberg Repatriation Hospital on 03 9496 2645 or nbric@unimelb.edu.au


Do you want to Lose Weight? Are you Planning Pregnancy in the next 6 months?
If the answer is YES, we want to hear from you!

Researchers are recruiting women aged 18-38 with a BMI>30 who wish to lose weight before planning to become pregnant in the next 6 months. Participants will be placed on a 3 month weight loss plan and will then be observed prior to and during pregnancy. Trial visits are held at the Metabolic Disorders Centre, Austin Health, Heidelberg Repatriation Hospital. All testing, treatment and parking will be provided free of charge. This study has been approved by the Austin Health and Melbourne Health Human Research Ethics Committee: HREC /14/MH/71
To find out more, contact Dr Sarah Price (03) 9496 6221 or sarah.price@unimelb.edu.au OR visit our website www.popstudy.com.au

Heart health/Stroke/Cholesterol (one studies/trials)

Heart Attack...Stroke...Are you at risk?

Heart attacks can happen at any time to anyone.  It is important to know if you are at risk. There are many factors that increase your chances of having a heart attack including:

  • Previous Heart Attack
  • Heart Related Disease
  • High Cholesterol
  • High Blood Pressure
  • Diabetes

Local physicians are conducting a research study of an investigational medication and its ability to reduce your risk of having a heart attack and other cardiovascular events such as a stroke.

If you are currently taking medication to lower your cholesterol and have one or more of the conditions listed above, you may qualify for participation in this study. To learn more, please contact Nicky Robinson on 03 9496 2645 or nbric@unimelb.edu.au.

This study has been approved by the Austin Health Human Research Ethics Committee.

Hepatology/ Liver

Looking for healthy volunteers

The Austin Liver Transplant Unit is conducting a study looking at an autoimmune liver disease called Primary Biliary Cirrhosis.

  • Primary biliary cirrhosis (PBC) is a chronic liver disease that can result in damage to the bile ducts within the liver which may lead to scarring of the liver
  • The causes of this disease are unknown at present
  • We are looking to see whether there are any environmental risk factors for this disease

We are looking for healthy controls without liver disease to be control subjects for the study. Your participation would involve a one-off interview, which would make a meaningful contribution to PBC research.

  • This will involve answering a questionnaire, having an examination and a blood test
  • We are looking for females and males from 30-90 years old

This study has been approved by the Austin Health Human Research Ethics Committee; HREC Reference Number H2013/04857.

If you are interested in participating, please contact Dr Janine French (Hepatology Fellow) on 03 9496 5353 or email janine.french@austin.org.au  for further information.

Kidney Function in Pregnancy Study

The Austin Endocrine Department, in collaboration with the Mercy Hospital for Women, is conducting a study looking at kidney function in pregnancy. 

We are looking for women aged less than 40 who are planning pregnancy or under 12 weeks pregnant. Eligible women will have their kidney function measured prior to (if applicable), during and after pregnancy.

This project has been approved by the Austin Health Human Research Ethics Committee.

If you are interested in participating, please contact Dr Jenny Huynh (Endocrine Fellow) on 03 9496 2260 or j.huynh4@pgrad.unimelb.edu.au for further information.

Melanoma (one study)

A Clinical research study is open to enrollment at Austin Health for patients with inoperable or metastatic melanoma to evaluate a new cancer vaccine in combination with Yervoy®. 

In order to participate, you must be:

-18+ years

- Have radiologically measurable disease

- Able to provide a tumour sample to test your suitability to participate

- At least 3 weeks since surgery at enrollment

- Able to meet other health related participation criteria

Patients enrolled on this study may be on the study for up to 12 months.  Details of this study can be found at http://clinicaltrials.gov/show/NCT01810016.  Please contact you oncologist or the Austin Health Cancer clinical Trials Centre on 03 9496 3088 to see if you may be suitable for this trial.

This study has been approved by the Austin Health Human Research Ethics Committee.

Men's Health (two studies/trials)

Testosterone replacement and diet therapy for weight loss in men
Recruitment for this trial is now closed 30 April 2014

We are conducting a one-year randomised, placebo-controlled weight loss trial investigating the use of testosterone therapy in addition to a very low calorie diet (Optifast).

We are seeking men, aged 18-75y with approximate weight 100-150kg who are not on any weight-altering medications, such as insulin.
Please note recruitment for this trial is now closed (30 April 2014)

Patients will be seen over one year and will have blood tests, X-ray scans and tests of muscle strength.

For more information, please contact Dr Mark Ng, Consultant Endocrinologist, 03 9496 2082 or mark.ng@unimelb.edu.au

This study has been approved by Austin Health HREC, study number H2012-04495

t4dm Study

Research into Preventing Diabetes Type 2 using Testosterone & Healthy Lifestyle

Free access to Weight Watchers

The Department of Medicine at Austin Health is recruiting men aged 50-74 years, with a waist circumference of 95cm or greater.

Participants would need to be available every 3 months for injection of testosterone or placebo & blood tests.

For further information or to screen yourself for eligibility go to: www.t4dm.org.au click on Join T4DM & complete questionnaire

or contact Jenny Healy on 03 9496 2282 or email t4dm-Austin@unimelb.edu.au

This trial has been approved by the Austin Health Human Research Ethics Committee

 

Osteoporosis

Are You Post Menopausal and Have Osteoporosis?

The Department of Bone Density at the Heidelberg Repatriation Hospital is currently recruiting patients for a clinical trial for post menopausal women with osteoporosis
.
You may be eligible to take part if you:

  • Have Osteoporosis
  • Are 55 - 90 years of age
  • You are taking not taking any osteoporosis medication.

The study will last for 1-2 years and is being performed at clinics throughout the world, including Australia.
If eligible to participate, you will receive study-related tests and study drug at no cost.
You will be reimbursed for parking and study-related travel expenses.
For more information, please contact: Christine Prosser on 9496 3600 or christine.prosser@austin.org.au
This study has been approved by the Austin Health Human Research Ethics Committee

Postnatal Depression

Internet-based Treatment for Women with Postnatal Depression

The Parent-Infant Research Institute at Austin Health is conducting a study to evaluate a new internet-based treatment program targeted for women experiencing postnatal depression. If you feel you are struggling to cope or experiencing postnatal depression, this program may be of benefit to you.

Each participant receives a phone assessment with a psychologist to discuss treatment options and to link you in with support services.

Participants will be randomly allocated to receive either the Internet-based treatment (MumMoodBooster) program, or routine primary care.

Participants will be asked to complete questionnaires and phone assessments at three time points over three months.

Each participant will be reimbursed for their time completing the questionnaires and for a telephone assessment interview ($35 in total).

The Internet-based treatment is free of charge.

This study has been approved by the Human Research Ethics Committee of Austin Health. For more information and eligibility criteria, contact the Parent-Infant Research Institute on 9496 4496 or piri@austin.org.au.

Spinal Cord Injury

Treatment of disordered blood pressure in spinal cord injury

The Blood Pressure Study will examine a new treatment to alleviate dizziness,fainting and other symptoms of low blood pressure in people with spinal cord injury. This study has just started at Austin Health, Melbourne, and is currently recruiting participants.

Many people have trouble with dizziness or fainting after a spinal cord injury when they get upright or remain upright for long periods of time. Other troublesome symptoms associated with low blood pressure are fatigue, difficulty coping with the heat and large amounts of urine at night. The disruption of the nervous system causes abnormalities in blood pressure control, so that the usual drop in blood pressure at night is lost.

This treatment aims to reduce the night time high blood pressure and urine over-production that contributes to the drop in blood pressure in the morning. This will reduce the fainting and nausea that occur in the morning and aid sleep and reduce the unpleasantness of high volumes of urine at night.

Weight loss (two studies/trials)

Do you have type 2 diabetes and are you concerned about your weight?

If yes, we are seeking volunteers with type 2 diabetes who are interested in participating in a placebo-controlled weight loss research study of an investigational medication.

 You may qualify for the trial if:

  • You are obese (Body Mass Index between 30-60 kg/m2)
  • You have Type 2 Diabetes
  • You are between 18-65 years of age
  • You must be willing to participate in a 52 week research study involving approximately 12 outpatient visits

For more information or to see if this trial is suitable for you, please contact Research Coordinator, Austin Health, Nicky 9496 2645 or email: ClinicalTrials-UoMrepat@unimelb.edu.au

This research study has been approved by the Austin Health Human Research Ethics Committee (HREC ZAF-203)

 
t4dm Study

Research into Preventing Diabetes Type 2 using Testosterone & Healthy Lifestyle

Free access to Weight Watchers

The Department of Medicine at Austin Health is recruiting men aged 50-74 years, with a waist circumference of 95cm or greater.

Participants would need to be available every 3 months for injection of testosterone or placebo & blood tests.

For further information or to screen yourself for eligibility go to: www.t4dm.org.au click on Join T4DM & complete questionnaire

or contact Jenny Healy on 03 9496 2282 or email t4dm-Austin@unimelb.edu.au

This trial has been approved by the Austin Health Human Research Ethics Committee