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"Quality is never an accident; it is always the result of high intention, sincere effort, intelligent direction, and skilful execution"
William Foster


Adverse effect – osteoporosis drug

The Therapeutic Goods Administration (TGA) has updated the product information for denosumab to include reference to QT prolongation and severe symptomatic hypocalcaemia. QT interval prolongation, tetany, seizures and altered mental status are examples of the clinical manifestations of severe symptomatic hypocalcaemia and clinicians are urged to monitor their patients.

Source: Medicines Safety Update 2016; 7(4)


Digital medicine system in psychiatry

An estimated 40%-50% of patients with serious mental illness are nonadherent to medication and this can compromise the effectiveness of antipsychotic treatments. "This article outlines the methodology and results from 3 early studies of a drug-device combination comprising a digital sensor embedded in a tablet, a wearable sensor and transmitter, and medical device data system software."

Source: Journal of Clinical Psychiatry 2016; online first: 2 August


Therapeutic music for cancer – Cochrane review

This updated review considered all studies investigating the effect of music interventions on psychological and physical outcomes in people with cancer. The authors concluded that music therapy may have a beneficial effect on anxiety, pain, fatigue and quality of life, and therefore recommend including it in psychosocial cancer care.

Source: Cochrane Database of Systematic Reviews 2016; 8


Hotspots of health inequalities in Vic & Qld

This Grattan Institute report looks at the potential to reduce preventable hospitalisations in hotspots within Victoria and Queensland. This could achieve direct & indirect savings of around $15 million a year. The Institute highlights that for each location a relatively small number of patients account for a substantial number of hospital readmissions. The report introduces a method of identifying small areas where health inequalities are entrenched and, without intervention, are likely to endure.

Source: Grattan Institute 2016


Aspirin for CVD prevention in diabetes: a meta-analysis

Patients with diabetes have a higher cardiovascular disease (CVD) event risk than patients without diabetes, and CVD is the leading cause of morbidity and mortality in this population. The authors evaluated the safety and efficacy of aspirin for the primary prevention of CVD in patients with diabetes concluding that "individual atherosclerotic events and mortality did not significantly differ in patients receiving aspirin versus those receiving placebo".

Source: Diabetes Research and Clinical Practice 2016; 120: 31-39


Medicine + Data + Technology - the EMR

What if people controlled their own health data? "It's 2021. Gavin logs into NHS.UK to change his privacy settings. He is concerned by several stories in the news about the way NHS services have been handling information about patients...." This quick essay helps us consider the value and constraints of the electronic medical record from a patient perspective.

Source: The King's Fund 2016


Austin Health Research Online - recent submissions

Potentially inappropriate medications and anticholinergic burden in older people attending memory clinics in Australia. Cross AJ, George J, Woodward MC, et. al. Drugs & Aging 2016; 33(1): 37-44

Reconciling concepts of space and person-centred care of the older person with cognitive impairment in the acute care setting. Rushton C, Edvardsson D. Nursing Philosophy 2016; online first: 26 July

Reference values for spirometry and their use in test interpretation: A Position Statement from the Australian and New Zealand Society of Respiratory Science. Brazzale D, Hall GP, Swanney MP. Respirology 2016; online first: 25 July

Vascular disruptive agent OXi4503 and anti-angiogenic agent Sunitinib combination treatment prolong survival of mice with CRC liver metastasis. Nguyen L, Fifis T, Christophi C. BMC Cancer 2016; 16: 533


eBooks spotlight

Sabiston & Spencer surgery of the chest [edited by] Frank W. Sellke, Pedro J. del Nido Scott J. Swanson – 9th ed. – Elsevier, 2016.
Available with over 20 procedural videos, this text provides information on the diagnosis and treatment of thoracic disease.

Sleisenger and Fordtran’s gastrointestinal and liver disease : pathophysiology / diagnosis / management / [edited by] Mark Feldman, Laurence S. Friedman, Lawrence J. Brandt – 10th ed. – Elsevier Saunders, 2015.
New chapters include up-to-date discussions of enteric microbiota, probiotics and faecal transplantation and factitious gastrointestinal disease; includes online videos.

New books on display
Caregiver stress and staff support in illness, dying, and bereavement / edited by Irene Renzenbrink – Oxford University Press, 2011.
This book discusses the management of caregiver stress. It covers the challenge of finding a balance between support needs of patients, families, and staff and the resources available.

An introduction to community and primary health / edited by Diana Guzys and Eileen  Petrie – Cambridge University Press, 2014.
"This book offers an engaging introduction to the theory, skills and application of community and primary health care in Australia."


Journals spotlight

These links provide access to the current table of contents:



International Journal of Medical Informatics

JACC: Cardiovascular Interventions

Journal of Music Therapy

Journal of Psychosomatic Research


The New England Journal of Medicine

Osteoporosis International

Telemedicine and E-Health

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