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"Researchers have discovered that chocolate produced some of the same reactions in the brain as marijuana. The researchers also discovered other similarities between the two, but can't remember what they are."
Matt Lauer

A happy and safe Easter from the Austin Library Team.


Clinical Communique - VIFM

This edition investigates deaths related to complications arising from day procedures: Post-operative pain - when to worry?; But the operation was months ago!; Don't dismiss the enlarging bruise. "Although the cases differed in the type of procedure being performed, common to all three was the failure to recognise rare complications. The seriousness of the evolving symptoms and signs were not fully appreciated by the patients or the clinicians until it was too late. Some of this can be attributed to knowledge gaps on the part of the doctors involved. Much of it can be related to inadequate discharge planning and poor post-operative communication."

Source: Clinical Communique. Victorian Institute of Forensic Medicine, 2016; 3(1)


Depression, TBI & hyperlipidemia: role of statins

We know that depression after traumatic brain injury (TBI) is common; "but does preexisting hyperlipidemia increase these patients' risk of having another depressive episode in the future?" The authors of this study investigate this question as well as the role of statin medications in new-onset depression using a longitudinal population database.

Source: Journal of Clinical Psychiatry 2016; Online first: 1 March


Parent-reported errors & adverse events in paediatrics

This US based study reports on the parents' perceptions of safety incidents affecting their children. This prospective cohort study was conducted in 2 general paediatric units at a children's hospital between May 2013 and October 2014. The authors concluded that "Parents frequently reported errors and preventable adverse events (AEs), many of which were not otherwise documented in the medical record. Families are an underused source of data about errors, particularly preventable AEs. Hospitals may wish to consider incorporating family reports into routine safety surveillance systems." These conclusions are consistent with other similar studies showing that patients and their families can add a useful perspective.

Source: JAMA Pediatrics 2016, online first: 29 February

Further reading

Source: Patient and Consumer Centred Care - Why partner with consumers? National Safety and Quality Health Service


Gluten: health menace or innocent bystander?

Is it a healthy lifestyle choice to follow a gluten free diet or completely unnecessary? Is this a social issue or a medical problem, and do clinicians have a role to play? This article opens the difficult conversation concerning gluten sensitivity and coeliac disease. In Australia 10% of the population "remove dietary wheat, the major source of gluten. For most (7%), the motivation is the presence of adverse symptoms, mainly gastrointestinal. Lethargy is also common." The author concludes that further research is needed to adequately diagnose and care for people who continue to suffer gastrointestinal symptoms after removing gluten from their diet.

Source: MJA 2016; 21 March

Further reading

Gut Microbiota and Coeliac Disease
This paper reviews the association between coeliac disease and gut microbiota. Research indicates that those at risk of developing coeliac disease have altered gut microbiota and it is thought to play a significant role in the pathogenesis of coeliac disease. The use of probiotics, in addition to a gluten free diet, in coeliac disease patients could "reduce the inflammatory response and restore a normal proportion of beneficial bacteria in the gastrointestinal tract. Additional evidence is needed in order to better understand the role of gut microbiota in the pathogenesis of celiac disease, and the clinical impact and therapeutic use of probiotics in this setting."
Source: Digestive Diseases and Sciences 2016; Online First: 2 January


Health benefits of legumes, pulses & Australian sweet lupins

The 68th United Nations General Assembly declared 2016 the International Year of Pulses. This paper outlines the evidence-based links between the consumption of legumes and a reduced risk of colorectal cancer as well as improvements in diabetes, cardiovascular disease and weight-management. "Sweet lupins are unique among legumes with one of the highest combined amounts of digestible plant protein (38%) and dietary fibre (30%). Unlike other legumes, their low amount of anti-nutritional factors negates the need for soaking/cooking and they can therefore be eaten uncooked. Sweet lupins may lower blood pressure, improve blood lipids and insulin sensitivity and favourably alter the gut microbiome."

Source: Asia Pacific Journal of Clinical Nutrition. 2016; 25(1): 1-17


Austin Health Research Online - recent submissions

Substantial variation in post-engraftment infection prophylaxis and revaccination practice in autologous stem cell transplant patients. Lim HY, Grigg A. Internal Medicine Journal 2016; 46(3): 347-351

Structure and function of the kidney in septic shock: a prospective controlled experimental study. Malden MJ, Otto S, Brealey JK, Finnis ME, Chapman MJ, Kuchel TR, Nash CH, Edwards J, Bellomo R. American Journal of Respiratory and Critical Care Medicine 2016; online first: 11 March

Colonoscopy in young women. Russell N, Stevenson AD. Internal Medicine Journal 2015; 45(11): 1198

Androgen receptor action in osteoblasts in male mice is dependent on their stage of maturation. Russell PK, Clarke MV, Cheong K, Anderson PH, Morris HA, Wiren KM, Zajac JD, Davey RA. Journal of Bone and Mineral Research 2015; 30(5): 809-823
Full text available for Austin & MHW Heidelberg staff via document delivery

See more at AHRO, Austin Health Research Online


eBooks spotlight

Bradley’s neurology in clinical practice / edited by Robert B. Daroff et al. - 7th ed. - Elsevier, 2016.
The book's practical straightforward style, evidence-based references and robust interactive content combine to make a dynamic resource for both practicing neurologists and trainees.

Emergency medicine secrets / edited by Vincent J. Markovchick et al. - 6th ed. - Elsevier, 2016.
The question and answer format also includes lists, mnemonics, tables and online interactive multiple choice questions for every chapter, making it a useful resource for both medical students and registrars.

Textbook of histology / Leslie P. Gartner - 4th ed. - Elsevier, 2017.
This concise, extensively illustrated text presents the basic science and clinical application of cellular and molecular biology that pertains to the subject matter of histology, and has been written with the student in mind.


Journals spotlight

These links provide access to the current table of contents:

American Journal of Transplantation

Health Care for Women International

International Journal of Health Governance (onsite access only)

Journal of Autoimmunity

Journal of Gastroenterology

Journal of Wound, Ostomy & Continence Nursing

Kidney International

Neurogastroenterology & Motility

Obesity Reviews

Pediatric Radiology

Sleep Medicine Reviews

Trends in Endocrinology & Metabolism


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