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"The only limit to our realisation of tomorrow will be our doubts of today."

Franklin D. Roosevelt

 

The statin diabetes conundrum

"Statin drugs have become the mainstay of many cardiovascular disease prevention guidelines and are recommended for most adult patients with diabetes. A careful review of the evidence, however, suggests that the clinical benefits of statins in diabetes may have been overstated...The statin-centric approach to preventing CHD may distract us from other therapies of proven benefit."

Source: Evidence-based medicine 15 July 2015, Online first.

 

Dementia: reducing prevalence, slowing progression

The road to reducing dementia onset and prevalence: are diet and physical activity interventions worth investing in?
In Australia, deaths as a result of dementia have now taken over cerebrovascular disease as the second leading cause of death. At present, over a quarter million Australians suffer from dementia and projected estimates indicate that the figure can reach a high of nearly one million by 2050. Research shows that higher ratios of saturated fat to monounsaturated fats are predictive of negative mental function. In addition, high mid-life serum cholesterol levels and excessive caloric intake have been found to be associated with impaired cognitive function.This issues brief outlines six integrated actions for reducing dementia onset and prevalence.

Source: Deeble Institute for Health Policy Research, 3 July 2015.

 

Clinical trials results and new data analyses in amyloid-related therapies
Clinical trial results from three studies of investigational therapies related to amyloid protein were presented this week at the Alzheimer's Association International Conference.
They included:

  • A new "delayed-start" analysis of negative Phase 3 clinical trials of solanezumab which suggests that the drug may slow the progression of mild Alzheimer's disease.
  • A biomarker-only analysis of a discontinued Phase 3 clinical trial of gantenerumab that shows the drug engaged its target in the brain and generated positive biological changes.
  • New data from PRIME, the Phase 1b study of aducanumab.

Source: AAIC 2015

 

 

BrowZine: mobile access for scholarly journals

The Library is running a trial of BrowZine, a new service that provides access to many of our licensed scholarly journals on your mobile device. Available for Android and iOS devices, BrowZine provides a great mechanism to keep track of your favourite journals and to learn about the new developments in your field. It allows you to easily see similar titles to the ones you are familiar with in order to broaden your knowledge of related scholarly literature.

With the BrowZine app, you can create a personal bookshelf of journals and save articles for off-line reading or export to services such as DropBox, EndNote, Zotero and more.

To learn more and start using BrowZine:

  • Download the app for free.
  • Select Austin Health as your library then login with your library barcode/PIN to start accessing subscription journals.
  • Send us your feedback: library@austin.org.au while we consider subscribing to this service.
Browzine
 

Gastrointestinal haemorrhage: review of care

This NCEPOD (National Confidential Enquiry into Patient Outcome and Death) report from the UK highlights the process of care for patients aged 16 years or older that were coded for a diagnosis of GI haemorrhage. The report takes a critical look at areas where the care of patients might have been improved. Remediable factors have also been identified in the clinical and the organisational care of these patients.

Source: Gastrointestinal haemorrhage: time to get control NCEPOD 2015

 

Genetics: markers and testing

Sparse whole-genome sequencing identifies two loci for major depressive disorder
New research has unearthed the first two genetic markers reproducibly linked to major depressive disorder, one of the leading causes of disability globally. Researchers suggest the results may provide a basis for future drug development or aid diagnosis.

Source: Nature 15 July, 2015
Full text available for Austin staff via document delivery.

Treatment decision making and genetic testing for breast cancer: mainstreaming mutations
"There is growing concern that clinicians are falling behind in their understanding of fundamental aspects of genetic testing and their confidence in discussing results with patients. An alternative viewpoint is that the use of genetic tests is outpacing the applicability of their findings to cancer treatment decisions." In this article the authors highlight the rapid increase in genetic testing for newly diagnosed breast cancers and indicate that "there is already a widening gap between the availability of more expansive genetic testing and the relative importance of results to treatment decisions".

Source: JAMA July 23, 2015 online first

DNA
 

Books spotlight

New books on display

Beyond the NICU : comprehensive care of the high-risk infant / edited by William F. Malcolm. McGraw Hill Education, 2015.
This text draws together clinically focused guidelines to improve patient outcomes and reduce hospital readmissions.

Change anything : the new science of personal success / Kerry Patterson et al. Business Plus, 2011.
This book provides readers with a collection of simple strategies to create personal success, by the authors of Crucial conversations : tools for talking when stakes are high.

Rutter's child and adolescent psychiatry / edited by Anita Thapar et al. Wiley, 2015.

eBook highlights

Harrison's principles of internal medicine / editors, Dennis L. Kasper et al. McGraw Hill Education, 2015.

Breast MRI / Virginia M. Molleran, Mary C. Mahoney. Elsevier Saunders, 2014.

Obstructive sleep apnoea / edited by Ferran Barbe and Jean-Louis Pepin. European Respiratory Society, 2015.
This monograph considers obstructive sleep apnoea from four different perspectives: pathogenesis; at-risk populations; clinical scenarios; and treatment and management.

 

Journals spotlight

These links provide access to the current table of contents:

Annals of internal medicine

Aphasiology

BMJ

British journal of psychiatry

Clinical genetics

Diabetes care

Emergency medicine Australasia

European respiratory journal

Evidence-based nursing

Journal of gastrointestinal surgery

Journal of perinatal medicine

Radiotherapy and oncology

Looking for the latest journal issues?
All our journal titles with electronic access are available via the A-Z Journal List
(outside the Austin Health network use your Library barcode no. & PIN for access)

If you require an article from a journal that is not in the A-Z Journal List, please use our online document delivery form.

 

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