A nurse checks on a patient in the cancer ward

Departments

Deputy Director

Prof Paul Johnson

MBBS, PhD, FRACP

Appointments

Deputy Director, Department of Infectious Diseases, Austin Health

Professor, University of Melbourne
Department of Microbiology and Immunology
Department of Medicine, Austin & Northern Clinical School

Clinical Associate, Victorian Infectious Diseases Reference Laboratory (VIDRL)

Director, World Health Organization Collaborating Centre for Mycobacterium ulcerans, Melbourne (located at VIDRL)

Member of Buruli ulcer Technical Advisory Group

 

Major Research Interests

Mycobacterium ulcerans - all aspects
Hospital infection control - MRSA, VRE, hand hygiene
Staphylococcus aureus - pathogenesis, resistance, epidemiology
Pandemic influenza

 

Recent Peer Reviewed Publications 

Omansen TF, Porter JL, Johnson PD, van der Werf TS, Stienstra Y, Stinear TP. In-vitro activity of avermectins against Mycobacterium ulcerans. PLoS Negl Trop Dis. 2015 Mar 5;9(3):e0003549. doi: 10.1371/journal.pntd.0003549. eCollection 2015 Mar. PubMed PMID: 25742173; PubMed Central PMCID: PMC4351077.

Coombs GW, Pearson JC, Daly DA, Le TT, Robinson JO, Gottlieb T, Howden BP, Johnson PD, Bennett CM, Stinear TP, Turnidge JD; Australian Group on Antimicrobial Resistance. Australian Enterococcal Sepsis Outcome Programme annual report, 2013. Commun Dis Intell Q Rep. 2014 Dec 31;38(4):E320-6. PubMed PMID: 25631594.

Abbott IJ, Papadakis G, Kaye M, Opdam H, Hutton H, Angus PW, Johnson PD, Kanellis J, Westall G, Druce J, Catton M. Laboratory identification of donor-derived coxsackievirus b3 transmission. Am J Transplant. 2015 Feb;15(2):555-9. doi: 10.1111/ajt.12986. Epub 2015 Jan 12. PubMed PMID: 25582147.

Coombs GW, Pearson JC, Le T, Daly DA, Robinson JO, Gottlieb T, Howden BP, Johnson PD, Bennett CM, Stinear TP, Turnidge JD; Australian Group on Antimicrobial Resistance. Australian Enterococcal Sepsis Outcome Progamme, 2011. Commun Dis Intell Q Rep. 2014 Sep 30;38(3):E247-52. PubMed PMID: 25391408.

Huang GK, Bond KA, Hewitt NH, Johnson PD. Measles: an important cause of fever and rash in a returned traveller. Med J Aust. 2014 Nov 17;201(10):605-6. PubMed PMID: 25390269.

Langan KM, Jacob J, Li J, Nation RL, Bellomo R, Howden B, Johnson PD. Pharmacokinetics of short versus extended infusion meropenem dosing in critically ill patients: a pilot study. Crit Care Resusc. 2014 Sep;16(3):190-6. PubMed PMID: 25161021.

Holmes NE, Turnidge JD, Munckhof WJ, Robinson JO, Korman TM, O'Sullivan MV, Anderson TL, Roberts SA, Warren SJ, Coombs GW, Tan HL, Gao W, Johnson PD, Howden BP. Genetic and molecular predictors of high vancomycin MIC in Staphylococcus aureus bacteremia isolates. J Clin Microbiol. 2014 Sep;52(9):3384-93. doi: 10.1128/JCM.01320-14. Epub 2014 Jul 16. PubMed PMID: 25031442; PubMed Central PMCID: PMC4313166.

Huang GK, Johnson PD. Epidemiology and management of Buruli ulcer. Expert Rev Anti Infect Ther. 2014 Jul;12(7):855-65. doi: 10.1586/14787210.2014.910113. Review. PubMed PMID: 24918117.

Knox J, Van Rijen M, Uhlemann AC, Miller M, Hafer C, Vavagiakis P, Shi Q, Johnson PD, Coombs G, Kluytmans-Van Den Bergh M, Kluytmans J, Bennett CM, Lowy FD. Community-associated methicillin-resistant Staphylococcus aureus transmission in households of infected cases: a pooled analysis of primary data from three studies across international settings. Epidemiol Infect. 2015 Jan;143(2):354-65. doi: 10.1017/S0950268814000983. Epub 2014 Apr 24. PubMed PMID: 24763185.

O'Brien DP, Jenkin G, Buntine J, Steffen CM, McDonald A, Horne S, Friedman ND, Athan E, Hughes A, Callan PP, Johnson PD. Treatment and prevention of Mycobacterium ulcerans infection (Buruli ulcer) in Australia: guideline update. Med J Aust. 2014 Mar 17;200(5):267-70. PubMed PMID: 24641151.

Johnson PD, Stuart RL. Clostridium difficile - what is the Australian story? Med J Aust. 2014 Mar 17;200(5):242-3. PubMed PMID: 24641129.

Carson C, Lavender CJ, Handasyde KA, O'Brien CR, Hewitt N, Johnson PD, Fyfe JA. Potential wildlife sentinels for monitoring the endemic spread of human buruli ulcer in South-East australia. PLoS Negl Trop Dis. 2014 Jan 30;8(1):e2668. doi: 10.1371/journal.pntd.0002668. eCollection 2014. PubMed PMID: 24498452; PubMed Central PMCID: PMC3907424.

O'Brien CR, Handasyde KA, Hibble J, Lavender CJ, Legione AR, McCowan C, Globan M, Mitchell AT, McCracken HE, Johnson PD, Fyfe JA. Clinical, microbiological and pathological findings of Mycobacterium ulcerans infection in three Australian Possum species. PLoS Negl Trop Dis. 2014 Jan 30;8(1):e2666. doi: 10.1371/journal.pntd.0002666. eCollection 2014. PubMed PMID: 24498451; PubMed Central PMCID: PMC3907337.

Kwong JC, Ward PB, Johnson PD. Cutaneous protothecosis in a patient with hypogammaglobulinemia. Med Mycol Case Rep. 2013 Jun 20;2:132-3. doi: 10.1016/j.mmcr.2013.06.002. eCollection 2013 Jun 20. PubMed PMID: 24432237; PubMed Central PMCID: PMC3885952.

Coombs GW, Pearson JC, Daley DA, Le T, Robinson OJ, Gottlieb T, Howden BP, Johnson PD, Bennett CM, Stinear TP, Turnidge JD; Australian Group on Antimicrobial Resistance. Molecular epidemiology of enterococcal bacteremia in Australia. J Clin Microbiol. 2014 Mar;52(3):897-905. doi: 10.1128/JCM.03286-13. Epub 2014 Jan 3. PubMed PMID: 24391201; PubMed Central PMCID: PMC3957796.

Stuart RL, Grayson ML, Johnson PD. Prevention of peripheral intravenous catheter-related bloodstream infections: the need for routine replacement. Med J Aust. 2013 Dec 16;199(11):751. PubMed PMID: 24329641.

Trubiano JA, Lavender CJ, Fyfe JA, Bittmann S, Johnson PD. The incubation period of Buruli ulcer (Mycobacterium ulcerans infection). PLoS Negl Trop Dis. 2013 Oct 3;7(10):e2463. doi: 10.1371/journal.pntd.0002463. eCollection 2013. PubMed PMID: 24098820; PubMed Central PMCID: PMC3789762.

Lam MM, Seemann T, Tobias NJ, Chen H, Haring V, Moore RJ, Ballard S, Grayson LM, Johnson PD, Howden BP, Stinear TP. Comparative analysis of the complete genome of an epidemic hospital sequence type 203 clone of vancomycin-resistant Enterococcus faecium. BMC Genomics. 2013 Sep 1;14:595. doi: 10.1186/1471-2164-14-595. PubMed PMID: 24004955; PubMed Central PMCID: PMC3846456.

Parbat N, Sherry N, Bellomo R, Schneider AG, Glassford NJ, Johnson PD, Bailey M. The microbiological and clinical outcome of guide wire exchanged versus newly inserted antimicrobial surface treated central venous catheters. Crit Care. 2013 Sep 3;17(5):R184. doi: 10.1186/cc12867. PubMed PMID: 24004883; PubMed Central PMCID: PMC4057507.

Li J, Chong AH, O'Keefe R, Johnson PD. The fish tank strikes again: metachronous nontuberculous mycobacterial skin infection in an immunosuppressed host. Australas J Dermatol. 2014 Nov;55(4):e77-9. doi: 10.1111/ajd.12094. Epub 2013 Aug 29. PubMed PMID: 23991645.

Howden BP, Holt KE, Lam MM, Seemann T, Ballard S, Coombs GW, Tong SY, Grayson ML, Johnson PD, Stinear TP. Genomic insights to control the emergence of vancomycin-resistant enterococci. MBio. 2013 Aug 13;4(4). pii: e00412-13. doi: 10.1128/mBio.00412-13. PubMed PMID: 23943759; PubMed Central PMCID: PMC3747580.

Karki S, Land G, Aitchison S, Kennon J, Johnson PD, Ballard SA, Leder K, Cheng AC. Long-term carriage of vancomycin-resistant enterococci in patients discharged from hospitals: a 12-year retrospective cohort study. J Clin Microbiol. 2013 Oct;51(10):3374-9. doi: 10.1128/JCM.01501-13. Epub 2013 Aug 7. PubMed PMID: 23926167; PubMed Central PMCID: PMC3811615.

Bennett CM, Coombs GW, Wood GM, Howden BP, Johnson LE, White D, Johnson PD. Community-onset Staphylococcus aureus infections presenting to general practices in South-eastern Australia. Epidemiol Infect. 2014 Mar;142(3):501-11. doi: 10.1017/S0950268813001581. Epub 2013 Jul 18. PubMed PMID: 23866772.

Stuart RL, Cameron DR, Scott C, Kotsanas D, Grayson ML, Korman TM, Gillespie EE, Johnson PD. Peripheral intravenous catheter-associated Staphylococcus aureus bacteraemia: more than 5 years of prospective data from two tertiary health services. Med J Aust. 2013 Jun 3;198(10):551-3. PubMed PMID: 23725270.

Trevillyan JM, Johnson PD. Steroids control paradoxical worsening of Mycobacterium ulcerans infection following initiation of antibiotic therapy. Med J Aust. 2013 May 6;198(8):443-4. PubMed PMID: 23641997.

Holmes NE, Ballard SA, Lam MM, Johnson PD, Grayson ML, Stinear TP, Howden BP. Genomic analysis of teicoplanin resistance emerging during treatment of vanB vancomycin-resistant Enterococcus faecium infections in solid organ transplant recipients including donor-derived cases. J Antimicrob Chemother. 2013 Sep;68(9):2134-9. doi: 10.1093/jac/dkt130. Epub 2013 Apr 23. PubMed PMID: 23612571.

Cowan R, Johnson PD, Urbancic K, Grayson ML. A timely reminder about the concomitant use of fusidic acid with statins. Clin Infect Dis. 2013 Jul;57(2):329-30. doi: 10.1093/cid/cit236. Epub 2013 Apr 15. PubMed PMID: 23588554.

Holmes NE, Turnidge JD, Munckhof WJ, Robinson JO, Korman TM, O'Sullivan MV, Anderson TL, Roberts SA, Warren SJ, Gao W, Johnson PD, Howden BP. Vancomycin minimum inhibitory concentration, host comorbidities and mortality in Staphylococcus aureus bacteraemia. Clin Microbiol Infect. 2013 Dec;19(12):1163-8. doi: 10.1111/1469-0691.12168. Epub 2013 Feb 26. PubMed PMID: 23441652.

Holmes NE, Turnidge JD, Munckhof WJ, Robinson JO, Korman TM, O'Sullivan MV, Anderson TL, Roberts SA, Warren SJ, Gao W, Howden BP, Johnson PD. Vancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia. Antimicrob Agents Chemother. 2013 Apr;57(4):1654-63. doi: 10.1128/AAC.01485-12. Epub 2013 Jan 18. PubMed PMID: 23335735; PubMed Central PMCID: PMC3623342.

van Ravensway J, Benbow ME, Tsonis AA, Pierce SJ, Campbell LP, Fyfe JA, Hayman JA, Johnson PD, Wallace JR, Qi J. Climate and landscape factors associated with Buruli ulcer incidence in Victoria, Australia. PLoS One. 2012;7(12):e51074. doi: 10.1371/journal.pone.0051074. Epub 2012 Dec 10. PubMed PMID: 23251425; PubMed Central PMCID: PMC3519496.

Boyapati R, Papadopoulos G, Olver J, Geluk M, Johnson PD. An unusual presentation of herpes simplex virus encephalitis. Case Rep Med. 2012;2012:241710. Epub 2012 Sep 6. PubMed PMID: 22991517; PubMed Central PMCID: PMC3443586.

Lavender CJ, Globan M, Johnson PD, Charles PG, Jenkin GA, Ghosh N, Clark BM, Martinello M, Fyfe JA. Buruli ulcer disease in travelers and differentiation of Mycobacterium ulcerans strains from northern Australia. J Clin Microbiol. 2012 Nov;50(11):3717-21. doi: 10.1128/JCM.01324-12. Epub 2012 Aug 8. PubMed PMID: 22875890; PubMed Central PMCID: PMC3486227.

Denholm JT, Leslie DE, Jenkin GA, Darby J, Johnson PD, Graham SM, Brown GV, Sievers A, Globan M, Brown LK, McBryde ES. Long-term follow-up of contacts exposed to multidrug-resistant tuberculosis in Victoria, Australia, 1995-2010. Int J Tuberc Lung Dis. 2012 Oct;16(10):1320-5. doi: 10.5588/ijtld.12.0092. Epub 2012 Aug 3. PubMed PMID: 22863690.

Mahony AA, Cheng AC, Olsen KL, Aboltins CA, Black JF, Johnson PD, Lindsay Grayson M, Torresi J. Diagnosing swine flu: the inaccuracy of case definitions during the 2009 pandemic, an attempt at refinement, and the implications for future planning. Influenza Other Respir Viruses. 2013 May;7(3):403-9. doi: 10.1111/j.1750-2659.2012.00398.x. Epub 2012 Jun 19. PubMed PMID: 22712880.

Holmes NE, Johnson PD, Howden BP. Relationship between vancomycin-resistant Staphylococcus aureus, vancomycin-intermediate S. aureus, high vancomycin MIC, and outcome in serious S. aureus infections. J Clin Microbiol. 2012 Aug;50(8):2548-52. doi: 10.1128/JCM.00775-12. Epub 2012 May 16. Review. PubMed PMID: 22593595; PubMed Central PMCID: PMC3421495.

Lam MM, Seemann T, Bulach DM, Gladman SL, Chen H, Haring V, Moore RJ, Ballard S, Grayson ML, Johnson PD, Howden BP, Stinear TP. Comparative analysis of the first complete Enterococcus faecium genome. J Bacteriol. 2012 May;194(9):2334-41. doi: 10.1128/JB.00259-12. Epub 2012 Feb 24. PubMed PMID: 22366422; PubMed Central PMCID: PMC3347086.

Teh B, Grayson ML, Johnson PD, Charles PG. Doxycycline vs. macrolides in combination therapy for treatment of community-acquired pneumonia. Clin Microbiol Infect. 2012 Apr;18(4):E71-3. doi: 10.1111/j.1469-0691.2011.03759.x. Epub 2012 Jan 27. PubMed PMID: 22284533.

Gordon CL, Holmes NE, Grayson ML, Torresi J, Johnson PD, Cheng AC, Charles PG. Comparison of immunoglobulin G subclass concentrations in severe community-acquired pneumonia and severe pandemic 2009 influenza A (H1N1) infection. Clin Vaccine Immunol. 2012 Mar;19(3):446-8. doi: 10.1128/CVI.05518-11. Epub 2012 Jan 11. PubMed PMID: 22237894; PubMed Central PMCID: PMC3294606.

Tong SY, Xie S, Richardson LJ, Ballard SA, Dakh F, Grabsch EA, Grayson ML, Howden BP, Johnson PD, Giffard PM. High-resolution melting genotyping of Enterococcus faecium based on multilocus sequence typing derived single nucleotide polymorphisms. PLoS One. 2011;6(12):e29189. doi: 10.1371/journal.pone.0029189. Epub 2011 Dec 16. PubMed PMID: 22195020; PubMed Central PMCID: PMC3241712.

Grayson ML, Ballard SA, Gao W, Khumra S, Ward P, Johnson PD, Grabsch EA. Quantitative efficacy of alcohol-based handrub against vancomycin-resistant enterococci on the hands of human volunteers. Infect Control Hosp Epidemiol. 2012 Jan;33(1):98-100. doi: 10.1086/663342. Epub 2011 Nov 22. PubMed PMID: 22173533.

Grayson ML, Russo PL, Cruickshank M, Bear JL, Gee CA, Hughes CF, Johnson PD, McCann R, McMillan AJ, Mitchell BG, Selvey CE, Smith RE, Wilkinson I. Outcomes from the first 2 years of the Australian National Hand Hygiene Initiative. Med J Aust. 2011 Nov 21;195(10):615-9. PubMed PMID: 22107015.

Teh B, Olsen K, Black J, Cheng AC, Aboltins C, Bull K, Johnson PD, Grayson ML, Torresi J. Impact of swine influenza and quarantine measures on patients and households during the H1N1/09 pandemic. Scand J Infect Dis. 2012 Apr;44(4):289-96. doi: 10.3109/00365548.2011.631572. Epub 2011 Nov 22. PubMed PMID: 22106922.

Gordon CL, Buntine JA, Hayman JA, Lavender CJ, Fyfe JA, Hosking P, Johnson PD. Spontaneous clearance of Mycobacterium ulcerans in a case of Buruli ulcer. PLoS Negl Trop Dis. 2011 Oct;5(10):e1290. doi: 10.1371/journal.pntd.0001290. Epub 2011 Oct 25. PubMed PMID: 22039555; PubMed Central PMCID: PMC3201911.

Chua KY, Seemann T, Harrison PF, Monagle S, Korman TM, Johnson PD, Coombs GW, Howden BO, Davies JK, Howden BP, Stinear TP. The dominant Australian community-acquired methicillin-resistant Staphylococcus aureus clone ST93-IV [2B] is highly virulent and genetically distinct. PLoS One. 2011;6(10):e25887. doi: 10.1371/journal.pone.0025887. Epub 2011 Oct 3. PubMed PMID: 21991381; PubMed Central PMCID: PMC3185049.

Lavender CJ, Fyfe JA, Azuolas J, Brown K, Evans RN, Ray LR, Johnson PD. Risk of Buruli ulcer and detection of Mycobacterium ulcerans in mosquitoes in southeastern Australia. PLoS Negl Trop Dis. 2011 Sep;5(9):e1305. doi: 10.1371/journal.pntd.0001305. Epub 2011 Sep 20. PubMed PMID: 21949891; PubMed Central PMCID: PMC3176747.

Eisen DP, Marshall C, Dean MM, Sasadeusz J, Richards M, Buising K, Cheng A, Johnson PD, Barr IG, McBryde ES. No association between mannose-binding lectin deficiency and H1N1 2009 infection observed during the first season of this novel pandemic influenza virus. Hum Immunol. 2011 Nov;72(11):1091-4. doi: 10.1016/j.humimm.2011.08.014. Epub 2011 Aug 28. PubMed PMID: 21920399.

Holmes NE, Turnidge JD, Munckhof WJ, Robinson JO, Korman TM, O'Sullivan MV, Anderson TL, Roberts SA, Gao W, Christiansen KJ, Coombs GW, Johnson PD, Howden BP. Antibiotic choice may not explain poorer outcomes in patients with Staphylococcus aureus bacteremia and high vancomycin minimum inhibitory concentrations. J Infect Dis. 2011 Aug 1;204(3):340-7. doi: 10.1093/infdis/jir270. PubMed PMID: 21742831.

Sarfo FS, Lavender CJ, Fyfe JA, Johnson PD, Stinear TP, Phillips RO. Mycobacterium ulcerans DNA not detected in faecal samples from Buruli ulcer patients: results of a pilot study. PLoS One. 2011 May 4;6(5):e19611. doi: 10.1371/journal.pone.0019611. PubMed PMID: 21573192; PubMed Central PMCID: PMC3087805.

Prowle JR, Echeverri JE, Ligabo EV, Sherry N, Taori GC, Crozier TM, Hart GK, Korman TM, Mayall BC, Johnson PD, Bellomo R. Acquired bloodstream infection in the intensive care unit: incidence and attributable mortality. Crit Care. 2011;15(2):R100. doi: 10.1186/cc10114. Epub 2011 Mar 21. PubMed PMID: 21418635; PubMed Central PMCID: PMC3219371.

Gordon CL, Langan K, Charles PG, Bellomo R, Hart GK, Torresi J, Johnson PD, Grayson ML. Pooled human immunoglobulin therapy in critically Ill patients with pandemic 2009 influenza A(H1N1) pneumonitis and immunoglobulin G2 subclass (IgG2) deficiency. Clin Infect Dis. 2011 Feb 1;52(3):422-6. doi: 10.1093/cid/ciq082. Epub 2010 Dec 16. PubMed PMID: 21217191.

Merritt RW, Walker ED, Small PL, Wallace JR, Johnson PD, Benbow ME, Boakye DA. Ecology and transmission of Buruli ulcer disease: a systematic review. PLoS Negl Trop Dis. 2010 Dec 14;4(12):e911. doi: 10.1371/journal.pntd.0000911. Review. PubMed PMID: 21179505; PubMed Central PMCID: PMC3001905.

Gordon CL, Buntine JA, Hayman JA, Lavender CJ, Fyfe JA, Hosking P, Starr M, Johnson PD. All-oral antibiotic treatment for buruli ulcer: a report of four patients. PLoS Negl Trop Dis. 2010 Nov 30;4(11):e770. doi: 10.1371/journal.pntd.0000770. PubMed PMID: 21152060; PubMed Central PMCID: PMC2994921.

Pidot SJ, Porter JL, Marsollier L, Chauty A, Migot-Nabias F, Badaut C, BĂ©nard A, Ruf MT, Seemann T, Johnson PD, Davies JK, Jenkin GA, Pluschke G, Stinear TP. Serological evaluation of Mycobacterium ulcerans antigens identified by comparative genomics. PLoS Negl Trop Dis. 2010 Nov 2;4(11):e872. doi: 10.1371/journal.pntd.0000872. PubMed PMID: 21072233; PubMed Central PMCID: PMC2970529.

Holmes NE, Gordon CL, Lightfoot N, Crowley P, Buchanan RR, Smith CL, Johnson PD. Intravascular large B cell lymphoma: an elusive cause of pyrexia of unknown origin diagnosed postmortem. Clin Infect Dis. 2010 Nov 1;51(9):e61-4. doi: 10.1086/656684. PubMed PMID: 20868278.

Johnson PD, Ballard SA, Grabsch EA, Stinear TP, Seemann T, Young HL, Grayson ML, Howden BP. A sustained hospital outbreak of vancomycin-resistant Enterococcus faecium bacteremia due to emergence of vanB E. faecium sequence type 203. J Infect Dis. 2010 Oct 15;202(8):1278-86. doi: 10.1086/656319. PubMed PMID: 20812846.

Howden BP, Seemann T, Harrison PF, McEvoy CR, Stanton JA, Rand CJ, Mason CW, Jensen SO, Firth N, Davies JK, Johnson PD, Stinear TP. Complete genome sequence of Staphylococcus aureus strain JKD6008, an ST239 clone of methicillin-resistant Staphylococcus aureus with intermediate-level vancomycin resistance. J Bacteriol. 2010 Nov;192(21):5848-9. doi: 10.1128/JB.00951-10. Epub 2010 Aug 27. PubMed PMID: 20802046; PubMed Central PMCID: PMC2953705.

Fyfe JA, Lavender CJ, Handasyde KA, Legione AR, O'Brien CR, Stinear TP, Pidot SJ, Seemann T, Benbow ME, Wallace JR, McCowan C, Johnson PD. A major role for mammals in the ecology of Mycobacterium ulcerans. PLoS Negl Trop Dis. 2010 Aug 10;4(8):e791. doi: 10.1371/journal.pntd.0000791. PubMed PMID: 20706592; PubMed Central PMCID: PMC2919402.