A nurse checks on a patient in the cancer ward

Departments

Prof Lindsay Grayson

Professor M Lindsay Grayson

MD, MSc, FRACP, FAFPHM, FRCP, FIDSA

Prof Lindsay Grayson graduated from Monash University Medical School in 1979 and completed Infectious Diseases training at New England Deaconess Hospital, Harvard Medical School, Boston in 1991; he completed his MD research thesis in 1994 and Master of Science (MSc) in Clinical Epidemiology & Clinical Effectiveness, Harvard School of Public Health, Boston in 1997. From 1991-2000, he was Deputy Director, then Director, of the Infectious Diseases and Clinical Epidemiology, Monash Medical Centre, Melbourne. Since 2000, Prof Grayson has been Director of Infectious Diseases and Microbiology, Austin Health and Professor of Infectious Diseases, Department of Medicine, University of Melbourne.

Prof Grayson is immediate past-President of the Australasian Society for Infectious Diseases and past-Chair of the Interscience Conference on Antimicrobial Agents & Chemotherapy (ICAAC) Program Committee for the American Society for Microbiology. He has had a longstanding interest in antimicrobial resistance, particularly related to staphylococci and enterococci and infection control. He is Editor-in-Chief of the ASM text, Kucers' "the Use of Antibiotics", 6th edition (2010) and co-editor of "Emerging Infections" (ASM, 2010).

 

Appointments

Director, Department of Infectious Diseases & Microbiology, Austin Health

Director, Hand Hygiene Australia

Professor, Department of Medicine, University of Melbourne

Editor-in-Chief, Kucers' "the Use of Antibiotics"


Recent Publications

Macesic N, Ameratunga M, Grayson ML, Johnson DF. Fever in melanoma: new drugs or bugs? Clin Microbiol Infect. 2015 Jun 25. pii: S1198-743X(15)00678-3. doi:10.1016/j.cmi.2015.06.020. [Epub ahead of print] PubMed PMID: 26119722.

Grayson ML, Macesic N, Trevillyan J, Ellis AG, Zeglinski PT, Hewitt NH, Gardiner BJ, Frauman AG. Fosfomycin for Treatment of Prostatitis: New Tricks for Old Dogs. Clin Infect Dis. 2015 Jun 10. pii: civ436. [Epub ahead of print] PubMed PMID: 26063723.

Rhodes NJ, Gardiner BJ, Neely MN, Grayson ML, Ellis AG, Lawrentschuk N, Frauman AG, Maxwell KM, Zembower TR, Scheetz MH. Optimal timing of oral fosfomycin administration for pre-prostate biopsy prophylaxis. J Antimicrob Chemother. 2015 Jul;70(7):2068-73. doi: 10.1093/jac/dkv067. Epub 2015 Mar 22. PubMed PMID: 25802286.

Korman TM, Turnidge JD, Grayson ML. Vancomycin vintage: my favourite DRESS. Intern Med J. 2015 Feb;45(2):233-4. doi: 10.1111/imj.12660. PubMed PMID: 25650542.

Grayson ML. Response to K. Page et al., 'Costing the Australian National Hand Hygiene Initiative'. J Hosp Infect. 2015 Feb;89(2):137-8. doi: 10.1016/j.jhin.2014.10.009. Epub 2014 Dec 11. PubMed PMID: 25555834.

Kwong JC, Grayson ML. TB-HAART trial. Lancet Infect Dis. 2015 Jan;15(1):14-5. doi: 10.1016/S1473-3099(14)71032-1. PubMed PMID: 25541161.

Cheah AL, Spelman T, Peel T, Howden BP, Spelman D, Grayson ML, Nation RL, Kong DC. Impact of vanB vancomycin-resistant enterococcal bacteraemia analysed as a time-varying covariate on length of hospital stay. Epidemiol Infect. 2014 Dec;142(12):2667-71. doi: 10.1017/S095026881400020X. PubMed PMID: 25372228.

Charles PG, Cheng AC, Grayson ML. It's time to move beyond trying to predict mortality using severity assessment tools in community-acquired pneumonia. Intern Med J. 2014 Nov;44(11):1148. doi: 10.1111/imj.12571. PubMed PMID: 25367733.

Stewardson AJ, Russo P, Grayson ML. Doctor, do you have a moment? National Hand Hygiene Initiative compliance in Australian hospitals. Med J Aust. 2014 Sep 1;201(5):264-5. PubMed PMID: 25163370.

Cheah AL, Peel T, Howden BP, Spelman D, Grayson ML, Nation RL, Kong DC. Case-case-control study on factors associated with vanB vancomycin-resistant and vancomycin-susceptible enterococcal bacteraemia. BMC Infect Dis. 2014 Jun 28;14:353. doi: 10.1186/1471-2334-14-353. PubMed PMID: 24973797; PubMed Central PMCID: PMC4091649.

Huang GK, Stewardson AJ, Grayson ML. Back to basics: hand hygiene and isolation. Curr Opin Infect Dis. 2014 Aug;27(4):379-89. doi: 10.1097/QCO.0000000000000080. PubMed PMID: 24945613; PubMed Central PMCID: PMC4086774.

Boak LM, Rayner CR, Grayson ML, Paterson DL, Spelman D, Khumra S, Capitano B, Forrest A, Li J, Nation RL, Bulitta JB. Clinical population pharmacokinetics and toxicodynamics of linezolid. Antimicrob Agents Chemother. 2014;58(4):2334-43. doi: 10.1128/AAC.01885-13. Epub 2014 Feb 10. PubMed PMID: 24514086; PubMed Central PMCID: PMC4023770.

Chua KY, Grayson ML, Burgess AN, Lee JY, Howden BP. The growing burden of multidrug-resistant infections among returned Australian travellers. Med J Aust. 2014 Feb 3;200(2):116-8. PubMed PMID: 24484117.

Stuart RL, Grayson ML, Johnson PD. Prevention of peripheral intravenous catheter-related bloodstream infections: the need for routine replacement. Med J Aust. 2013 Dec 16;199(11):751. PubMed PMID: 24329641.

Gardiner BJ, Mahony AA, Ellis AG, Lawrentschuk N, Bolton DM, Zeglinski PT, Frauman AG, Grayson ML. Is fosfomycin a potential treatment alternative for multidrug-resistant gram-negative prostatitis? Clin Infect Dis. 2014 Feb;58(4):e101-5. doi: 10.1093/cid/cit704. Epub 2013 Oct 28. PubMed PMID: 24170195.

Grabsch EA, Xie S, Szczurek PB, Grayson ML, Howden BP. Assessment of the BD GeneOhm MRSA ACP assay using combined swabs for the detection of methicillin resistant Staphylococcus aureus (MRSA) colonisation. Pathology. 2013 Oct;45(6):612-4. doi: 10.1097/PAT.0b013e3283653b48. PubMed PMID: 24018809.

Howden BP, Holt KE, Lam MM, Seemann T, Ballard S, Coombs GW, Tong SY, Grayson ML, Johnson PD, Stinear TP. Genomic insights to control the emergence of vancomycin-resistant enterococci. MBio. 2013 Aug 13;4(4). pii: e00412-13. doi: 10.1128/mBio.00412-13. PubMed PMID: 23943759; PubMed Central PMCID: PMC3747580.

Trevillyan J, Angus P, Shelton E, Whitlam J, Ierino F, Pavlovic J, Gregory D, Urbancic K, Torresi J, Testro A, Grayson ML. Electronic estimations of renal function are inaccurate in solid-organ transplant recipients and can result in significant underdosing of prophylactic valganciclovir. Antimicrob Agents Chemother. 2013 Aug;57(8):4058-60. doi: 10.1128/AAC.00375-13. Epub 2013 Jun 3. PubMed PMID: 23733466; PubMed Central PMCID: PMC3719737.

Stuart RL, Cameron DR, Scott C, Kotsanas D, Grayson ML, Korman TM, Gillespie EE, Johnson PD. Peripheral intravenous catheter-associated Staphylococcus aureus bacteraemia: more than 5 years of prospective data from two tertiary health services. Med J Aust. 2013 Jun 3;198(10):551-3. PubMed PMID: 23725270.

Holmes NE, Ballard SA, Lam MM, Johnson PD, Grayson ML, Stinear TP, Howden BP. Genomic analysis of teicoplanin resistance emerging during treatment of vanB vancomycin-resistant Enterococcus faecium infections in solid organ transplant recipients including donor-derived cases. J Antimicrob Chemother. 2013 Sep;68(9):2134-9. doi: 10.1093/jac/dkt130. Epub 2013 Apr 23. PubMed PMID: 23612571.

Cowan R, Johnson PD, Urbancic K, Grayson ML. A timely reminder about the concomitant use of fusidic acid with statins. Clin Infect Dis. 2013 Jul;57(2):329-30. doi: 10.1093/cid/cit236. Epub 2013 Apr 15. PubMed PMID: 23588554.

Johnson DF, Ratnam I, Matchett E, Earnest-Silveria L, Christiansen D, Leder K, Grayson ML, Torresi J. The incidence of HBV and HCV infection in Australian travelers to Asia. J Travel Med. 2013 May-Jun;20(3):203-5. doi: 10.1111/jtm.12029. PubMed PMID: 23577867.

Cheah AL, Spelman T, Liew D, Peel T, Howden BP, Spelman D, Grayson ML, Nation RL, Kong DC. Enterococcal bacteraemia: factors influencing mortality, length of stay and costs of hospitalization. Clin Microbiol Infect. 2013 Apr;19(4):E181-9.  doi: 10.1111/1469-0691.12132. Epub 2013 Feb 7. PubMed PMID: 23398607.

Gardiner BJ, Grayson ML, Wood GM. Inducible resistance to clindamycin in Staphylococcus aureus: validation of Vitek-2 against CLSI D-test. Pathology. 2013 Feb;45(2):181-4. doi: 10.1097/PAT.0b013e32835cccda. PubMed PMID: 23277176.

Grabsch EA, Mahony AA, Cameron DR, Martin RD, Heland M, Davey P, Petty M, Xie S, Grayson ML. Significant reduction in vancomycin-resistant enterococcus colonization and bacteraemia after introduction of a bleach-based cleaning-disinfection programme. J Hosp Infect. 2012 Dec;82(4):234-42. doi: 10.1016/j.jhin.2012.08.010. Epub 2012 Oct 25. PubMed PMID: 23103245.

Grayson ML, Russo PL. Problematic linkage of publicly disclosed hand hygiene compliance and health care-associated Staphylococcus aureus bacteraemia rates: comment. Med J Aust. 2012 Aug 20;197(4):212-4; author reply 214. PubMed PMID: 22900863.

Grayson ML, Charles PG, Howden BP. A potential "blind spot" in vancomycin treatment studies. Clin Infect Dis. 2012 Jul;55(1):165. doi: 10.1093/cid/cis333. Epub 2012 Mar 29. PubMed PMID: 22460956.

Lam MM, Seemann T, Bulach DM, Gladman SL, Chen H, Haring V, Moore RJ, Ballard S, Grayson ML, Johnson PD, Howden BP, Stinear TP. Comparative analysis of the first complete Enterococcus faecium genome. J Bacteriol. 2012 May;194(9):2334-41. doi: 10.1128/JB.00259-12. Epub 2012 Feb 24. PubMed PMID: 22366422; PubMed Central PMCID: PMC3347086.

Teh B, Grayson ML, Johnson PD, Charles PG. Doxycycline vs. macrolides in combination therapy for treatment of community-acquired pneumonia. Clin Microbiol Infect. 2012 Apr;18(4):E71-3. doi: 10.1111/j.1469-0691.2011.03759.x. Epub 2012 Jan 27. PubMed PMID: 22284533.

Gordon CL, Holmes NE, Grayson ML, Torresi J, Johnson PD, Cheng AC, Charles PG. Comparison of immunoglobulin G subclass concentrations in severe community-acquired pneumonia and severe pandemic 2009 influenza A (H1N1) infection. Clin Vaccine Immunol. 2012 Mar;19(3):446-8. doi: 10.1128/CVI.05518-11. Epub 2012 Jan 11. PubMed PMID: 22237894; PubMed Central PMCID: PMC3294606.

Pulcini C, Bush K, Craig WA, Frimodt-Møller N, Grayson ML, Mouton JW, Turnidge J, Harbarth S, Gyssens IC; ESCMID Study Group for Antibiotic Policies. Forgotten antibiotics: an inventory in Europe, the United States, Canada, and Australia. Clin Infect Dis. 2012 Jan 15;54(2):268-74. doi: 10.1093/cid/cir838. Review. PubMed PMID: 22198992.

Tong SY, Xie S, Richardson LJ, Ballard SA, Dakh F, Grabsch EA, Grayson ML, Howden BP, Johnson PD, Giffard PM. High-resolution melting genotyping of Enterococcus faecium based on multilocus sequence typing derived single nucleotide polymorphisms. PLoS One. 2011;6(12):e29189. doi: 10.1371/journal.pone.0029189. Epub 2011 Dec 16. PubMed PMID: 22195020; PubMed Central PMCID: PMC3241712.

Grayson ML, Ballard SA, Gao W, Khumra S, Ward P, Johnson PD, Grabsch EA. Quantitative efficacy of alcohol-based handrub against vancomycin-resistant enterococci on the hands of human volunteers. Infect Control Hosp Epidemiol. 2012 Jan;33(1):98-100. doi: 10.1086/663342. Epub 2011 Nov 22. PubMed PMID: 22173533.

Grayson ML, Russo PL, Cruickshank M, Bear JL, Gee CA, Hughes CF, Johnson PD, McCann R, McMillan AJ, Mitchell BG, Selvey CE, Smith RE, Wilkinson I. Outcomes from the first 2 years of the Australian National Hand Hygiene Initiative. Med J Aust. 2011 Nov 21;195(10):615-9. PubMed PMID: 22107015.

Teh B, Olsen K, Black J, Cheng AC, Aboltins C, Bull K, Johnson PD, Grayson ML, Torresi J. Impact of swine influenza and quarantine measures on patients and households during the H1N1/09 pandemic. Scand J Infect Dis. 2012 Apr;44(4):289-96. doi: 10.3109/00365548.2011.631572. Epub 2011 Nov 22. PubMed PMID: 22106922.

Moellering RC Jr, Corey GR, Grayson ML. Introduction: fusidic acid enters the United States. Clin Infect Dis. 2011 Jun;52 Suppl 7:S467-8. doi: 10.1093/cid/cir171. PubMed PMID: 21546622.

Gordon CL, Langan K, Charles PG, Bellomo R, Hart GK, Torresi J, Johnson PD, Grayson ML. Pooled human immunoglobulin therapy in critically Ill patients with pandemic 2009 influenza A(H1N1) pneumonitis and immunoglobulin G2 subclass (IgG2) deficiency. Clin Infect Dis. 2011 Feb 1;52(3):422-6. doi: 10.1093/cid/ciq082. Epub 2010 Dec 16. PubMed PMID: 21217191.

Chua K, Laurent F, Coombs G, Grayson ML, Howden BP. Antimicrobial resistance: Not community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)! A clinician's guide to community MRSA - its evolving antimicrobial resistance and implications for therapy. Clin Infect Dis. 2011 Jan 1;52(1):99-114. doi: 10.1093/cid/ciq067. Review. PubMed PMID: 21148528.

Johnson PD, Ballard SA, Grabsch EA, Stinear TP, Seemann T, Young HL, Grayson ML, Howden BP. A sustained hospital outbreak of vancomycin-resistant Enterococcus faecium bacteremia due to emergence of vanB E. faecium sequence type 203. J Infect Dis. 2010 Oct 15;202(8):1278-86. doi: 10.1086/656319. PubMed PMID: 20812846.