Oncologist Dr. Belinda Yeoh and a patient

Departments

A/Prof Pat Charles

A/Prof Patrick Charles

MBBS, PhD, FRACP

Appointments

Physician, Department of Infectious Diseases, Austin Health
Head of Unit, General Medicine 3, Austin Health
Supervisor of HMO 2 & 3 training, Austin Health
Honorary Lecturer, University of Melbourne

 

Major Research Activities & Interests

Faecal microbiota transplantation

Urinary bacteriotherapy

The emergence of antibiotic-resistance pathogens

Community-acquired pneumonia - aetiology, treatment choices, severity assessment

Nursing home-acquired infections - aetiology, treatment choices

Pandemic H1N1 influenza - epidemiology and treatment

Improving antibiotic use

Dengue fever immunisation

 

Recent peer-reviewed publications

Charles PG, Uçkay I, Kressmann B, Emonet S, Lipsky BA. The role of anaerobes in diabetic foot infections. Anaerobe. 2015 Apr 2;34:8-13. doi: 10.1016/j.anaerobe.2015.03.009. [Epub ahead of print] Review. PubMed PMID: 25841893.

Charles PG, Cheng AC, Grayson ML. It's time to move beyond trying to predict mortality using severity assessment tools in community-acquired pneumonia. Intern Med J. 2014 Nov;44(11):1148. doi: 10.1111/imj.12571. PubMed PMID: 25367733.

Said MA, Johnson HL, Nonyane BA, Deloria-Knoll M, O'Brien KL; AGEDD Adult Pneumococcal Burden Study Team, Andreo F, Beovic B, Blanco S, Boersma WG, Boulware DR, Butler JC, Carratalà J, Chang FY, Charles PG, Diaz AA, Domínguez J, Ehara N, Endeman H, Falcó V, Falguera M, Fukushima K, Garcia-Vidal C, Genne D, Guchev IA, Gutierrez F, Hernes SS, Hoepelman AI, Hohenthal U, Johansson N, Kolek V, Kozlov RS, Lauderdale TL, Mareković I, Masiá M, Matta MA, Miró Ò, Murdoch DR, Nuermberger E, Paolini R, Perelló R, Snijders D, Plečko V, Sordé R, Strålin K, van der Eerden MM, Vila-Corcoles A, Watt JP. Estimating the burden of pneumococcal pneumonia among adults: a systematic review and meta-analysis of diagnostic techniques. PLoS One. 2013;8(4):e60273. doi: 10.1371/journal.pone.0060273. Epub 2013 Apr 2. Review. PubMed PMID: 23565216; PubMed Central PMCID: PMC3615022.

Xie C, Charles PG, Urbancic K. Inappropriate ceftriaxone use in the emergency department of a tertiary hospital in Melbourne, Australia. Emerg Med Australas. 2013 Feb;25(1):94-6. doi: 10.1111/1742-6723.12037. PubMed PMID: 23379463.

Crawford NW, Cheng A, Andrews N, Charles PG, Clothier HJ, Day B, Day T, Gates P, Macdonell R, Roberts L, Rodriguez-Casero V, Wijeratne T, Kiers L. Guillain-Barré syndrome following pandemic (H1N1) 2009 influenza A immunisation in Victoria: a self-controlled case series. Med J Aust. 2012 Nov 19;197(10):574-8. Erratum in: Med J Aust. 2014 Apr 7;200(6):321. Macdonnell, Richard [corrected to Macdonell, Richard]. PubMed PMID: 23163689.

Trubiano JA, Gardiner B, Kwong JC, Ward P, Testro AG, Charles PG. Faecal microbiota transplantation for severe Clostridium difficile infection in the intensive care unit. Eur J Gastroenterol Hepatol. 2013 Feb;25(2):255-7. doi: 10.1097/MEG.0b013e32835b2da9. PubMed PMID: 23117471.

Lavender CJ, Globan M, Johnson PD, Charles PG, Jenkin GA, Ghosh N, Clark BM, Martinello M, Fyfe JA. Buruli ulcer disease in travelers and differentiation of Mycobacterium ulcerans strains from northern Australia. J Clin Microbiol. 2012 Nov;50(11):3717-21. doi: 10.1128/JCM.01324-12. Epub 2012 Aug 8. PubMed PMID: 22875890; PubMed Central PMCID: PMC3486227.

Grayson ML, Charles PG, Howden BP. A potential "blind spot" in vancomycin treatment studies. Clin Infect Dis. 2012 Jul;55(1):165. doi: 10.1093/cid/cis333. Epub 2012 Mar 29. PubMed PMID: 22460956.

Kwong JC, Chua K, Charles PG. Managing Severe Community-Acquired Pneumonia Due to Community Methicillin-Resistant Staphylococcus aureus (MRSA). Curr Infect Dis Rep. 2012 Jun;14(3):330-8. doi: 10.1007/s11908-012-0254-8. PubMed PMID: 22430229.

Teh B, Grayson ML, Johnson PD, Charles PG. Doxycycline vs. macrolides in combination therapy for treatment of community-acquired pneumonia. Clin Microbiol Infect. 2012 Apr;18(4):E71-3. doi: 10.1111/j.1469-0691.2011.03759.x. Epub 2012 Jan 27. PubMed PMID: 22284533.

Gordon CL, Holmes NE, Grayson ML, Torresi J, Johnson PD, Cheng AC, Charles PG. Comparison of immunoglobulin G subclass concentrations in severe community-acquired pneumonia and severe pandemic 2009 influenza A (H1N1) infection. Clin Vaccine Immunol. 2012 Mar;19(3):446-8. doi: 10.1128/CVI.05518-11. Epub 2012 Jan 11. PubMed PMID: 22237894; PubMed Central PMCID: PMC3294606.

Kwong JC, Howden BP, Charles PG. New aspirations: the debate on aspiration pneumonia treatment guidelines. Med J Aust. 2011 Oct 3;195(7):380-1. PubMed PMID: 21978335.

Xie C, Taylor DM, Howden BP, Charles PG. Comparison of the bacterial isolates and antibiotic resistance patterns of elderly nursing home and general community patients. Intern Med J. 2012 Jul;42(7):e157-64. doi: 10.1111/j.1445-5994.2011.02436.x. PubMed PMID: 21241444.

Gordon CL, Langan K, Charles PG, Bellomo R, Hart GK, Torresi J, Johnson PD, Grayson ML. Pooled human immunoglobulin therapy in critically Ill patients with pandemic 2009 influenza A(H1N1) pneumonitis and immunoglobulin G2 subclass (IgG2) deficiency. Clin Infect Dis. 2011 Feb 1;52(3):422-6. doi: 10.1093/cid/ciq082. Epub 2010 Dec 16. PubMed PMID: 21217191.

Charles PG. Predicting CAP-related mortality with CRB-65. Thorax. 2011 Mar;66(3):262; author reply 262-3. doi: 10.1136/thx.2009.133884. Epub 2010 Oct 14. PubMed PMID: 20947893.